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Strain Detail: mTRAX Tg#4 mice

Strain information
Resource No. nbio273
Strain name mTRAX Tg#4
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6JJmsSlc
Institution Department of Immunology, National Institute of Infectious Deseases
Developer Masataka Kasai
Depositor Masataka Kasai
Conditions of distribution

In publishing the research results obtained by use of the animal resource, a citation of the following literature and the stipulation of an acknowledgment to depositor designated by the depositor is requested. It's necessary to obtain depositor's consent on use of biological resources.contact us
Animal Health Report
Strain description

The mTRAX Tg#4 mice are transgenic mice expressing CAG-promoter-driven mouse trax in the whole body. The trax and translin (TSN) form a complex that works as a Mg2+-dependent endoribonuclease in the core RNAi machinery (Science 325(5941):750-753, 2009). A study using TSN KO mice (Nbio055) revealed that loss of microRNA in dicer deficiency is caused by TSN/Trax RNase (Cell Reports 9(4):1471-81, 2014). The strain is useful for analyzing various developmental abnormalities caused by dicer deficiency.
Reference(s)
  1. Aoki K, Ishida R, and Kasai M. (1997) Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX. FEBS Lett 401(2-3):109-12. [PMID:9013868]
Resource information
Cryopreserved sperm In-house Genotype Tg/+
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Tsn
Gene name Translin
Genotyping information