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Strain Detail

Strain information
Resource No. nbio129
Strain name 11Enh-Cre
Strain Nomenclature
Common name/Synonyms LI-Cre, 742-Cre-Int
Strain types mutant
Background strain
Institution Department of Bone and Cartilage Biology, Osaka University Graduate School of Medicine
Developer Noriyuki Tsumaki
Depositor Noriyuki Tsumaki
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

11Enh-Cre mice express Cre in chondrocytes. This strain is used for conditional transgenic mouse system (Cre/loxP system). Cre regulated by Col11a2 (Type XI collagen alpha 2 chain gene) promoter/intron 1 enhancer. This strain is used for elucidation of in vivo roles of Smad7 about chondrocyte differentiation by specifically expressing Smad7 in chondrocytes after the late stage of proliferative chondrocytes by mating with Col11a2-LacZflox-Smad7 mouse (nbio127). This strain expects to contribute to basic research for the therapy of motor system diseases in orthopedics.

References
  1. Iwai T, Murai J, Yoshikawa H, Tsumaki N (2008) Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways. J Biol Chem 283:27154-27164. [PMID: 18644788]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Col11a2, Cre
Gene name Collagen, type XI, alpha 2, Cre recombinase
Genotyping information Genotyping PCR protocol for 11Enh-Cre mice (pdf).