HOME > mice > 11Enh-Cre mice
Strain Detail: 11Enh-Cre mice
| Strain information |
| Resource No. |
nbio129 |
| Strain name |
11Enh-Cre |
| Strain Nomenclature |
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| Common name/Synonyms |
LI-Cre, 742-Cre-Int |
| Strain types |
mutant |
| Background strain |
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| Institution |
Department ofBoneand Cartilage Biology, Osaka University Graduate School of Medicine |
| Developer |
Noriyuki Tsumaki |
| Depositor |
Yasufumi Kaneda (Vice Director、Co-creation Bureau, Osaka University) |
| Conditions of distribution |
It's necessary to obtain depositor's consent on use ofbiologicalresources. :contact us |
| Animal Health Report |
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| Strain description |
11Enh-Cre mice express Cre in chondrocytes. This strain is used for conditional transgenic mouse system (Cre/loxP system). Cre regulated by Col11a2 (Type XI collagen alpha 2 chain gene) promoter/intron 1 enhancer. This strain is used for elucidation of in vivo roles of Smad7 about chondrocyte differentiation by specifically expressing Smad7 in chondrocytes after the late stage of proliferative chondrocytes by mating with Col11a2-LacZflox-Smad7 mouse (nbio127). This strain expects to contribute to basic research for the therapy of motor system diseases in orthopedics. |
| Reference(s) |
- Iwai T, Murai J, Yoshikawa H, Tsumaki N (2008) Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways. J Biol Chem 283:27154-27164. [PMID: 18644788]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
FERTIUP |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
