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Strain Detail: 129+Ter/Sv-Pros1 K196E NCVC mice

Strain information
Resource No. nbio280
Strain name 129+Ter/Sv-Pros1 K196E NCVC
Strain Nomenclature
Common name/Synonyms PS-K196E knockin(129)
Strain types congenic
Background strain 129+Ter/Sv Jcl
Institution Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute
Developer Toshiyuki Miyata
Depositor Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

The PS-K196E knockin (129) mice are knock-in mice carrying c.586A>G (p.K196E) mutation introduced in Pros1 locus of 129+Ter/Sv mice by knock-in technology. Pros1 gene encodes a blood coagulation control factor, protein S.

  1. Banno F, Kita T, Fernández JA, Yanamoto H, Tashima Y, Kokame K, Griffin JH, and Miyata T. (2015) Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation. Blood 126(19):2247-53. [PMID:26251307]
Resource information
Cryopreserved sperm In-house Genotype Pros1 E/E homozygous
From other institutions Genotype
Cryopreserved embryo In-house Mating System Natural mating - perfusion
Genotype Mix of Pros1 E/E homozygous and heterozygous
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Please contact us
Gene information
Mutation types knockin
Gene symbol Pros1
Gene name protein S (α)
Genotyping information