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Strain Detail: 129+Ter/Sv-Pros1 K196E NCVC

Strain information
Resource No. nbio280
Strain name 129+Ter/Sv-Pros1 K196E NCVC
Strain Nomenclature
Common name/Synonyms PS-K196E knockin(129)
Strain types congenic
Background strain 129+Ter/Sv Jcl
Institution Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute
Developer Toshiyuki Miyata
Depositor Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

The PS-K196E knockin (129) mice are knock-in mice carrying c.586A>G (p.K196E) mutation introduced in Pros1 locus of 129+Ter/Sv mice by knock-in technology. Pros1 gene encodes a blood coagulation control factor, protein S.

  1. Banno F, Kita T, Fernández JA, Yanamoto H, Tashima Y, Kokame K, Griffin JH, Miyata T. Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation. Blood. 2015, 126(19):2247-53.
Resource information
Cryopreserved sperm In-house Genotype Pros1 E/E homozygous
From other institutions Genotype
Cryopreserved embryo In-house Mating System Natural mating - perfusion
Genotype Mix of Pros1 E/E homozygous and heterozygous
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse Please contact us
Gene information
Mutation types knockin
Gene symbol Pros1
Gene name protein S (α)
Genotyping information