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Strain Detail: Conditional KO (14-3-3 epsilon) mice

Strain information
Resource No. nbio316
Strain name Conditional KO (14-3-3 epsilon)
Strain Nomenclature
Common name/Synonyms 14-3-3 epsilon cKO
Strain types mutant
Background strain C57BL/6J
Institution (1) Department of Pharmacology, National Research Institute for Child Health and Development, (2) UNITECH Co., Ltd.
Developer Junji Yamauchi (1) and Hisashi Tomaru (2)
Depositor Junji Yamauchi (1) and Hisashi Tomaru (2)
Conditions of distribution

Collaboration with the depositor only. In publishing the research results obtained by use of the biological resource, a citation of the following literature and the stipulation of an acknowledgment to depositor are requested. It's necessary to obtain depositor's consent on use of biological resources. : contact us

Animal Health Report
Strain description

The 14-3-3 proteins, a family of seven isomers, are involved in the intracellular signal transduction by regulating monoamine synthesis. In mammals, the 14-3-3 proteins exist at extremely high concentrations in brains and spinal cords, suggesting that the proteins might be involved in neurological diseases.

This strain of mice has a floxed exon in 14-3-3 epsilon gene. The 14-3-3 epsilon gene can be silenced (knocked out) by the mating with Cre mice. The strain can be used as a research tool for functional studies of 14-3-3 epsilon in the central nervous system.

Reference(s)
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm
Cryopreserved embryo
Live animals
Gene information
Mutation types conditional KO
Gene symbol Ywhae (14-3-3 epsilon´╝ë
Gene name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Genotyping information