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Strain Detail: Aars2-flox mice

Strain information
Resource No. nbio430
Strain name Aars2-flox
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N
Institution Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition
Developer Osamu Suzuki
Depositor Osamu Suzuki
Conditions of distribution Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

Floxed mice of the Aars2 gene, one of the causative genes for progressive leukoencephalopathy. Two loxPs have been inserted into introns 2 and 4 of the Aars2 gene by genome editing (Cre causes the removal of exons 3-4). The mice are expected to be used as conditional knockout mice in the study of progressive leukoencephalopathy.

Resource information
Cryopreserved sperm In-house Genotype Homozygous
Medium Fertiup
From other institutions Genotype
Cryopreserved embryo In-house Mating System homozygous sperm x C57BL/6NCr Slc
Genotype heterozygous
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types conditional KO
Gene symbol Aars2
Gene name alanyl-tRNA synthetase 2, mitochondrial
Genotyping information