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Strain Detail: ACE2 Tg #17

Strain information
Resource No. nbio298
Strain name ACE2 Tg #17
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6J Jms Slc
Institution National Institute of Infectious Diseases
Developer Kiyoshi Tanabayashi
Depositor Kiyoshi Tanabayashi
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Animal Health Report
Strain description

The ACE2 Tg #17 mice are transgenic mice carrying CAG-promoter-driven human angiotensin I converting enzyme 2 (hACE2), a receptor for SARS Coronavirus (SARS-CoV). The mice express hACE2 in the whole body and are highly susceptible to SARS-CoV. The strain is useful as a mouse model for SARS-CoV infection. Three lines are available (#5, #16, #17). In Japan, users of this strain need permission for recombinant DNA experiments from the Minister of Education, Culture, Sports, Science and Technology.

References
Resource information
Cryopreserved sperm In-house Genotype Tg/+
Medium R18S3
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo
Live animals Approx. 3 months
Gene information
Mutation types spontaneous mutation
Gene symbol ACE2
Gene name angiotensin I converting enzyme 2
Genotyping information