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Strain Detail: ACE2 Tg #17 mice

Strain information
Resource No. nbio298
Strain name ACE2 Tg #17
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6J Jms Slc
Institution National Institute of Infectious Diseases
Developer Kiyoshi Tanabayashi
Depositor Kiyoshi Tanabayashi
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Animal Health Report
Strain description

The ACE2 Tg #17 mice are transgenic mice carrying CAG-promoter-driven human angiotensin I converting enzyme 2 (hACE2), a receptor for SARS Coronavirus (SARS-CoV). The mice express hACE2 in the whole body and are highly susceptible to SARS-CoV. The strain is useful as a mouse model for SARS-CoV infection. Three lines are available (#5, #16, #17). In Japan, users of this strain need permission for recombinant DNA experiments from the Minister of Education, Culture, Sports, Science and Technology.
Reference(s)
  1. Asaka MN, Utsumi D, Kamada H, Nagata S, Nakachi Y, Yamaguchi T, Kawaoka Y, Kuba K, and Yasutomi Y. (2021) Highly susceptible SARS-CoV-2 model in CAG promoter-driven hACE2-transgenic mice. JCI Insight 6(19):e152529. [PMID:34463644]
Resource information
Cryopreserved sperm In-house Genotype Tg/+
Medium R18S3
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo
Live animals Approx. 3 months
Gene information
Mutation types spontaneous mutation
Gene symbol ACE2
Gene name angiotensin I converting enzyme 2
Genotyping information