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Strain Detail: AK mice
| Strain information | |
|---|---|
| Resource No. | nbio017 |
| Strain name | AK |
| Strain Nomenclature | |
| Common name/Synonyms | |
| Strain types | mutant |
| Background strain | C57BL/6NCr Slc |
| Institution | National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)(formerly, National Institute of Infectious Diseases) |
| Developer | Junichiro Matsuda |
| Depositor | Junichiro Matsuda |
| Conditions of distribution | without conditions: contact us |
| Animal Health Report | |
| Strain description | GM1-gangliosidosis is classified three forms: infantile, juvenile and adult, according to the age of onset or clinical manifestation. Each clinical form has a human β-Gal gene mutation. GalA mice express mutant human β-Gal I51T found in adult form. AK mice were produced by introducing human β-Gal I51T gene into β-Gal KO (BKO) mice. |
| Reference(s) | |
| Resource information | |||
|---|---|---|---|
| Cryopreserved sperm | In-house | Genotype | Tg/+, β-Gal (+/-) |
| Medium | FERTIUP | ||
| From other institutions | Genotype | ||
| Medium | |||
| Cryopreserved embryo | In-house | Mating System | |
| Genotype | Tg/+, β-Gal (+/-), β-Gal (-/-) | ||
| Medium | EFS40 | ||
| From other institutions | Mating System | ||
| Genotype | |||
| Method | |||
| Strain status / Availability | Cryopreserved sperm | Within 1 month | |
| Cryopreserved embryo | Within 1 month | ||
| Live animals | Approx. 2 months | ||
| Gene information | |
|---|---|
| Mutation types | transgenic + knockout |
| Gene symbol | Glb1 |
| Gene name | galactosidase, beta 1 |
| Genotyping information | |