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Strain Detail: AMPK-CA/B mice

Strain information
Resource No. nbio089
Strain name AMPK-CA/B
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Division of basic nutrition, National Institute of Health and Nutrition
Developer Shinji Miura
Depositor Shinji Miura
Conditions of distribution

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Animal Health Report
Strain description

AMPK-CA/B mice are transgenic mice specifically overexpressing rat constitutive active AMPK α1 subunit in skeletal muscle. This strain expresses transgene introduced T172D mutation into cDNA encoding amino acids 1-312 of rat AMPK α1 subunit under the control of human α actin promoter on -2,000 bp. However, these mice didn't observe to increase AMPK activity in skeletal muscle. AMPK is an enzyme phosphorylating protein in the presence of AMP, and it's hetero trimer constructed with three subunit, α, β and γ. This strain is availabale for research about obesity and diabetes because AMPK regulates enzyme activity related to carbohydrate or lipid metabolism. This strain has 4 lines.

Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Ampk
Gene name AMP-activated protein kinase
Genotyping information