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Strain Detail: B6N Albino-Blvra-/- mice

Strain information
Resource No. nbio370
Strain name B6N Albino-Blvra-/-
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N (albino)
Institution Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University
Developer Michiyuki Matsuda
Depositor Michiyuki Matsuda
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

The strain is deficient for the Biliverdin Reductase-A (Blvra) gene. Biliverdin is required for the color development of fluorescent dyes (NIR FP) that emit near infrared rays such as iRFP. Increasing the biliverdin concentration due to Blvra deficiency has the advantage of facilitating observation of NIR FP in vivo. Blvra-/- mice are versatile tools for in vivo applications of NIRFP and NIR light-sensing optogenetic tools.

  1. Kobachi K, Kuno S, Sato S, Sumiyama K, Matsuda M, Terai K. (2020) Biliverdin reductase-A deficiency brighten and sensitize biliverdin-binding chromoproteins. Cell Struct Funct. 45:131-141. [PMID: 32581154]
Resource information
Cryopreserved sperm In-house Genotype homozygous
From other institutions Genotype
Cryopreserved embryo In-house Mating System
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo
Live animals Approx. 2 months
Gene information
Mutation types Knockout
Gene symbol Blvra
Gene name Biliverdin Reductase-A
Genotyping information