HOME > mice > B6N Albino-Blvra-/- mice
Strain Detail: B6N Albino-Blvra-/- mice
| Strain information |
| Resource No. |
nbio370 |
| Strain name |
B6N Albino-Blvra-/- |
| Strain Nomenclature |
|
| Common name/Synonyms |
|
| Strain types |
mutant |
| Background strain |
C57BL/6N (albino) |
| Institution |
Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University |
| Developer |
Michiyuki Matsuda |
| Depositor |
Michiyuki Matsuda |
| Conditions of distribution |
It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
|
| Strain description |
The strain is deficient for the Biliverdin Reductase-A (Blvra) gene. Biliverdin is required for the color development of fluorescent dyes (NIR FP) that emit near infrared rays such as iRFP. Increasing the biliverdin concentration due to Blvra deficiency has the advantage of facilitating observation of NIR FP in vivo. Blvra-/- mice are versatile tools for in vivo applications of NIRFP and NIR light-sensing optogenetic tools. |
| Reference(s) |
- Kobachi K, Kuno S, Sato S, Sumiyama K, Matsuda M, Terai K. (2020) Biliverdin reductase-A deficiency brighten and sensitize biliverdin-binding chromoproteins. Cell Struct Funct. 45:131-141. [PMID: 32581154]
|
| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
homozygous |
| Medium |
|
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
|
| Genotype |
|
| Medium |
|
| From other institutions |
Mating System |
|
| Genotype |
|
| Method |
|
| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
|
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
Knockout |
| Gene symbol |
Blvra |
| Gene name |
Biliverdin Reductase-A |
| Genotyping information |
|
