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Strain Detail: Bloc1s6-KO mice

Strain information
Resource No. nbio361
Strain name Bloc1s6-KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N
Institution Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition
Developer Osamu Suzuki
Depositor Osamu Suzuki
Conditions of distribution Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description Comparison of coat colors

A mouse strain in which Bloc1s6, one of the genes responsible for Hermansky-Pudlak syndrome (HPS), is knocked out by genome editing (CRISPR/Cas9). It was created by deleting the coding sequence near the 5'-end with two gRNAs to the Bloc1s6 gene. Homozygous KO mice have a paler coat color than C57BL/6N wild-type mice (B6 mice, see photos). The strain is expected to be used as an HPS model. Bloc1s6-KO mice often exhibit torticollis, maybe due to abnormal otolith formation (Erway et al., 1971).

  1. Erway LC, Fraser AS, and Hurley LS. (1971) Prevention of congenital otolith defect in pallid mutant mice by manganese supplementation. Genetics 67(1):97-108. [PMID:5559839]
Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Bloc1s6
Gene name biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
Genotyping information