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Strain Detail: C57BL/6J-Plg A622T NCVC

Strain information
Resource No. nbio281
Strain name C57BL/6J-Plg A622T NCVC
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute
Developer Toshiyuki Miyata
Depositor Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution

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Animal Health Report
Strain description

This strain is a knock-in mouse strain carrying c.1864G>A (p.A622T) mutation introduced in Plg locus of C57BL/6J mice.

A race-specific A620T mutation in Plg, also known as Plg-Tochigi, originally identified in a patient with recurrent venous thromboembolism, causes dysplasminogenemia with reduced plasmin activity. The Plg-A620T mutation is present in 3±4% of individuals in East Asian populations, and as many as 50,000 Japanese are estimated to be homozygous for the mutant 620T allele.

References
  1. Tashima Y, Banno F, Kita T, Matsuda Y, Yanamoto H, and Miyata T. (2017) Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions. PLoS ONE 12(7):e0180981. [PMID:28686706]
Resource information
Cryopreserved sperm In-house Genotype Homozygous
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System IVF
Genotype Heterozygous
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockin
Gene symbol Plg
Gene name plasminogen
Genotyping information