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Strain Detail: C57BL/6J-Pros1 KO + Plg A622T NCVC

Strain information
Resource No. nbio291
Strain name C57BL/6J-Pros1 KO + Plg A622T NCVC
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute
Developer Toshiyuki Miyata
Depositor Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution

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Animal Health Report
Strain description

This strain is a knockin/knockout mouse strain carrying Pros1 knockout and Plg knockin (A622T) alleles with C57BL/6J background.

References
  1. Tashima Y, Banno F, Kita T, Matsuda Y, Yanamoto H, and Miyata T. (2017) Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions. PLoS ONE 12(7):e0180981. [PMID:28686706]
Resource information
Cryopreserved sperm In-house Genotype Pros1: KO/wild, Plg: KI/KI
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System IVF
Genotype Pros1: mix of heterozygous and wild-type, Plg: heterozygous
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockin
Gene symbol Pros1, Plg
Gene name protein S, plasminogen
Genotyping information