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Strain Detail: Conditional KO（CD69） mice
| Strain information | |
|---|---|
| Resource No. | nbio315 |
| Strain name | Conditional KO（CD69） |
| Strain Nomenclature | |
| Common name/Synonyms | CD69 cKO |
| Strain types | mutant |
| Background strain | C57BL/6J |
| Institution | (1) Department of Pharmacology, National Research Institute for Child Health and Development, (2) UNITECH Co., Ltd. |
| Developer | Junji Yamauchi (1) and Hisashi Tomaru (2) |
| Depositor | Junji Yamauchi (1) and Hisashi Tomaru (2) |
| Conditions of distribution | Collaboration with the depositor only. In publishing the research results obtained by use of the biological resource, a citation of the following literature and the stipulation of an acknowledgment to depositor are requested. It's necessary to obtain depositor's consent on use of biological resources. : contact us |
| Animal Health Report | |
| Strain description | CD69 proteins are expressed as an cell-surface protein in activated lymphocytes and macropahges, as well as some other blood cells. The protein is thought to be involved in the autoimmune and allergic diseases. This strain of mice has a floxed exon in Cd69 gene. The Cd69 gene can be silenced (knocked out) by the mating with Cre mice. The strain can be used as a research tool for functional studies of Cd69 in a wide variety of immune diseases. |
| Reference(s) | |
| Resource information | |||
|---|---|---|---|
| Cryopreserved sperm | In-house | Genotype | |
| Medium | |||
| From other institutions | Genotype | ||
| Medium | |||
| Cryopreserved embryo | In-house | Mating System | |
| Genotype | |||
| Medium | |||
| From other institutions | Mating System | ||
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| Method | |||
| Strain status / Availability | Cryopreserved sperm | ||
| Cryopreserved embryo | |||
| Live animals | |||
| Gene information | |
|---|---|
| Mutation types | conditional KO |
| Gene symbol | Cd69 |
| Gene name | CD69 antigen |
| Genotyping information | |