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Strain Detail: Cftr-KO mice
| Strain information |
| Resource No. |
nbio379 |
| Strain name |
Cftr-KO |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Osamu Suzuki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
A mouse strain in which the Cftr gene was knocked out by genome editing (CRISPR / Cas9). It was created by setting gRNAs at two exons 4 and 6 of the Cftr gene and deleting the middle part of the coding region. However, no frameshift has occurred since the deletion, and it is possible that mutant proteins are produced. The Cftr gene is the causative gene of cystic fibrosis and is suggested to be involved in pulmonary fibrosis. This strain is useful for studying these diseases. |
| Reference(s) |
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
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| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Cftr |
| Gene name |
cystic fibrosis transmembrane conductance regulator |
| Genotyping information |
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