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Strain Detail: Cftr-KO mice

Strain information
Resource No. nbio379
Strain name Cftr-KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N
Institution Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition
Developer Osamu Suzuki
Depositor Osamu Suzuki
Conditions of distribution Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

A mouse strain in which the Cftr gene was knocked out by genome editing (CRISPR / Cas9). It was created by setting gRNAs at two exons 4 and 6 of the Cftr gene and deleting the middle part of the coding region. However, no frameshift has occurred since the deletion, and it is possible that mutant proteins are produced. The Cftr gene is the causative gene of cystic fibrosis and is suggested to be involved in pulmonary fibrosis. This strain is useful for studying these diseases.

Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Cftr
Gene name cystic fibrosis transmembrane conductance regulator
Genotyping information