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Strain Detail: Ct55 KO mice

Strain information
Resource No. nbio376
Strain name Ct55 KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6
Institution Lab. of Genome-Chromosome Functions, Institute for Protein Research, Osaka University
Developer Akira Shinohara
Depositor Akira Shinohara
Conditions of distribution Users shall give an acknowledgment to the depositor when publishing the research results. Users shall obtain the consent of the depositor in advance. contact us
Animal Health Report
Strain description

Knockout mice for the Ct55 gene, produced by genome editing. The cancer testis antigen 55 (CT55) is expressed in different tumors and normal testes. CT55 is involved in colitis-associated cancer as a new potent promoter (Zhao et al., 2019). A deficiency of the cancer/testis antigen gene CT55 causes male infertility in humans and mice (Zhang et al., 2022). This strain is useful for the study of cancer and spermatogenesis.
Reference(s)
  1. Zhao H, Pan WM, Zhang HH, Song Y, Chen J, Xiang Y, Gu B, Li SZ, Du RL, and Zhang XD. (2019) Cancer testis antigen 55 deficiency attenuates colitis-associated colorectal cancer by inhibiting NF-κB signaling. Cell Death Dis 10(4):304. [PMID:30944312]
  2. Zhang G, Jiang C, Yang Y, Wang Y, Zhou H, Dai S, Liu M, Yang Y, Yang L, Shen Q, Zhang T, Zhang X, Yang Y, and Shen Y. (2022) Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice. Cell Death Differ (in press). [PMID:36481789]
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm
Cryopreserved embryo
Live animals Only live mice are available (Approx. 2 months).
Gene information
Mutation types knockout
Gene symbol Ct55
Gene name Cancer/testis antigen 55
Genotyping information