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Strain Detail: Cyth2-KI mice

Strain information
Resource No. nbio425
Strain name Cyth2-KI
Strain Nomenclature
Common name/Synonyms Cyth2-Y381F
Strain types mutant
Background strain
Institution (1)Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy & Life Science, (2) UNITECH Co., Ltd.
Developer Junji Yamauchi (1) and Hisashi Tomaru (2)
Depositor Junji Yamauchi (1) and Hisashi Tomaru (2)
Conditions of distribution Limited to collaborative research with depositors. The user must cite the reference (Ref. 1) provided by the depositors when publishing the research results. Users shall give an acknowledgment to the depositors when publishing the research results. Prior consent of the depositors for the use of biological resources is required. contact us
Animal Health Report
Strain description

Knockin mice with a nonphosphorylatable Y381F mutation in cytohesin-2. The knockin mice exhibited reduced myelin thickness and decreased Arf6 activity in sciatic nerve tissue.

  1. Miyamoto Y, Torii T, Homma K, Oizumi H, Ohbuchi K, Mizoguchi K, Takashima S, and Yamauchi J. (2022) The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice. Sci Signal 15(718):eabi5276. [PMID:35077201]
Resource information
Cryopreserved sperm In-house Genotype homozygous and heterozygous
Medium Fertiup
From other institutions Genotype
Cryopreserved embryo In-house Mating System
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo
Live animals Approx. 2 months
Gene information
Mutation types knock-in
Gene symbol Cyth2
Gene name cytohesin 2
Genotyping information