HOME > mice > Cyth2-KI mice
Strain Detail: Cyth2-KI mice
| Strain information |
| Resource No. |
nbio425 |
| Strain name |
Cyth2-KI |
| Strain Nomenclature |
|
| Common name/Synonyms |
Cyth2-Y381F |
| Strain types |
mutant |
| Background strain |
|
| Institution |
(1)Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy & Life Science, (2) UNITECH Co., Ltd. |
| Developer |
Junji Yamauchi (1) and Hisashi Tomaru (2) |
| Depositor |
Junji Yamauchi (1) and Hisashi Tomaru (2) |
| Conditions of distribution |
Limited to collaborative research with depositors. The user must cite the reference (Ref. 1) provided by the depositors when publishing the research results. Users shall give an acknowledgment to the depositors when publishing the research results. Prior consent of the depositors for the use of biological resources is required. contact us |
| Animal Health Report |
|
| Strain description |
Knockin mice with a nonphosphorylatable Y381F mutation in cytohesin-2. The knockin mice exhibited reduced myelin thickness and decreased Arf6 activity in sciatic nerve tissue. |
| Reference(s) |
- Miyamoto Y, Torii T, Homma K, Oizumi H, Ohbuchi K, Mizoguchi K, Takashima S, and Yamauchi J. (2022) The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice. Sci Signal 15(718):eabi5276. [PMID:35077201]
|
| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
homozygous and heterozygous |
| Medium |
Fertiup |
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
|
| Genotype |
|
| Medium |
|
| From other institutions |
Mating System |
|
| Genotype |
|
| Method |
|
| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
|
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knock-in |
| Gene symbol |
Cyth2 |
| Gene name |
cytohesin 2 |
| Genotyping information |
|
