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Strain Detail

Strain information
Resource No. nbio234
Strain name Derlin-1 KO
Strain Nomenclature C57BL/6J-Derl1tmNCVC
Common name/Synonyms
Strain types mutant
Background strain
Institution Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute
Developer Toshiyuki Miyata
Depositor Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1) designated by the depositor is requested. It's necessary to obtain depositor's consent on use of biological resources.: contact us
Animal Health Report
Strain description

Derlin-1 KO mice are knockout mice of Derl1 gene. This strain is embryonic lethal at 7-8 days embryonic age. Derlin-1 is a endoplasmic reticulum membrane protein and the member of Derlin family.

References
  1. Eura Y, Yanamoto H, Arai Y, Okuda T, Miyata T, Kokame K. Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice. PLoS One. 2012;7(3):e34298.
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Derl1
Gene name derlin 1
Genotyping information