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Strain Detail: Derlin-3 KO mice

Strain information
Resource No. nbio235
Strain name Derlin-3 KO
Strain Nomenclature C57BL/6J-Derl3tmNCVC
Common name/Synonyms
Strain types mutant
Background strain
Institution Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute
Developer Toshiyuki Miyata
Depositor Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1) designated by the depositor is requested. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

Derlin-3 KO mice are knockout mice for the Derl3 gene. These mice are born normally according to Mendelian inheritance. In organs, such as the liver, the expression levels of ER-associated degradation (ERAD) related proteins were affected under normal and ER stress conditions. This strain is expected as a useful model to elucidate the relationship between ERAD and stress or pathologic conditions. Derlin-3 is an endoplasmic reticulum membrane protein and a member of the Derlin family.
Reference(s)
  1. Eura Y, Yanamoto H, Arai Y, Okuda T, Miyata T, and Kokame K. (2012) Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice. PLoS One 7(3):e34298. [PMID:22479592]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Derl3
Gene name derlin 3
Genotyping information