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Strain Detail: Col11a2-lacZ-dnTgfbr2-#1 mice

Strain information
Resource No. nbio172
Strain name Col11a2-lacZ-dnTgfbr2-#1
Strain Nomenclature
Common name/Synonyms DTR#1
Strain types mutant
Background strain
Institution Department ofBoneand Cartilage Biology, Osaka University Graduate School of Medicine
Developer Noriyuki Tsumaki
Depositor Yasufumi Kaneda (Vice Director、Co-creation Bureau, Osaka University)
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

Col11a2-lacZ-dnTgfbr2-#1 mice are loxP mice to construct cartilaginous conditional transgenic mouse system and regulated transgene expression by Col11a2 (Type XI collagen alpha 2 chain gene) promoter/intron 1 enhancer. The double transgenic mouse produced by mating between Col11a2-lacZ-dnTgfbr2-#1 mouse and Prx1-Cre mouse specifically expresses dominant-negative TGFβ receptor type II in the cartilage. This strain expects to contribute to basic research for the therapy of motor system diseases in orthopedics, such as dyschondroplasia.
Reference(s)
  1. Hiramatsu K, Iwai T, Yoshikawa H, and Tsumaki N. (2011) Expression of dominant negative TGF-β receptors inhibits cartilage formation in conditional transgenic mice. J Bone Miner Metab 29(4):493-500. [PMID:21213115]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types conditional transgenic
Gene symbol Tgfbr2
Gene name Transforming growth factor, beta receptor II
Genotyping information