HOME > mice > Fah2 KO mice
Strain Detail: Fah2 KO mice
| Strain information |
| Resource No. |
nbio470 |
| Strain name |
Fah2 KO |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6J |
| Institution |
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University |
| Developer |
Akio Kihara |
| Depositor |
Akio Kihara |
| Conditions of distribution |
Users shall give an acknowledgment to the depositors when publishing the research results. contact us |
| Animal Health Report |
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| Strain description |
Knockout mice of the Fa2h gene produced by genome editing. Fa2h is Fatty acid 2-hydroxylase, an enzyme that introduces a hydroxyl group to the 2nd position of fatty acids. The 2-OH fatty acids synthesized by Fa2h are the constituent lipids of galactosylceramide, which is abundant in myelin in the brain, and wax diesters, which are abundant in mouse sebum. For this reason, Fa2h knockout mice show phenotypes such as progressive motor impairment and hair loss. |
| Reference(s) |
- Potter KA, Kern MJ, Fullbright G, Bielawski J, Scherer SS, Yum SW, Li JJ, Cheng H, Han X, Venkata JK, Khan PA, Rohrer B, and Hama H. (2011) Central nervous system dysfunction in a mouse model of FA2H deficiency. Glia 59(7):1009-21. [PMID:21491498]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
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| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Fa2h |
| Gene name |
fatty acid 2-hydroxylase |
| Genotyping information |
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