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Strain Detail

Strain information
Resource No. nbio047
Strain name FAT-CDO
Strain Nomenclature
Common name/Synonyms aP2-CDO mice
Strain types mutant
Background strain
Institution Division of basic nutrition, National Institute of Health and Nutrition
Developer
Depositor Nobuyo Kasaoka
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

FAT-CDO mice are transgenic mice overexpressing specifically rat cysteine dioxygenase (CDO) in fat tissue. CDO, a rate-limiting enzyme of taurine synthesis, is expected to promote taurine synthesis in fat tissue. Transgene is designed including aP2 promoter. This strain overexpresses 2-3 times CDO in fat tissue compared with normal mice. This strain are available for research of metabolic syndolome or relationship between taurine and obesity.

References
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Cdo
Gene name Cysteine dioxygenase
Genotyping information