HOME > mice > FAT-UCP2/X mice
Strain Detail: FAT-UCP2/X mice
| Strain information |
| Resource No. |
nbio026 |
| Strain name |
FAT-UCP2/X |
| Strain Nomenclature |
|
| Common name/Synonyms |
aP2-UCP2 mice |
| Strain types |
mutant |
| Background strain |
|
| Institution |
Division of basic nutrition, National Institute of Health and Nutrition |
| Developer |
Nobuyo Kasaoka |
| Depositor |
Nobuyo Kasaoka |
| Conditions of distribution |
It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
|
| Strain description |
FAT-UCP2/X mice are transgenic mice overexpressing specifically human UCP2 in fat tissue. This strain is expected to suppress lipid accumulation and it's available for research about therapy and prevention of human obesity or diabetes. X line used 5.4 kb aP2 promoter and enhancer expresses approximately 15 times human UCP2 compared with normal mice. Furthermore, UCP2 is one of the uncoupling protein related to energy consumption/thermogenesis to uncouple oxidative phosphorylation in the mitochondrial inner membrane, and it expresses extensively in organs. |
| Reference(s) |
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
|
| Medium |
FERTIUP |
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
|
| Genotype |
|
| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
|
| Method |
|
| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
transgenic |
| Gene symbol |
Ucp2 |
| Gene name |
Uncoupling protein 2 |
| Genotyping information |
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