HOME > mice > FAT-UCP2/X mice

Strain Detail

Strain information
Resource No. nbio026
Strain name FAT-UCP2/X
Strain Nomenclature
Common name/Synonyms aP2-UCP2 mice
Strain types mutant
Background strain
Institution Division of basic nutrition, National Institute of Health and Nutrition
Developer Nobuyo Kasaoka
Depositor Nobuyo Kasaoka
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

FAT-UCP2/X mice are transgenic mice overexpressing specifically human UCP2 in fat tissue. This strain is expected to suppress lipid accumulation and it's available for research about therapy and prevention of human obesity or diabetes. X line used 5.4 kb aP2 promoter and enhancer expresses approximately 15 times human UCP2 compared with normal mice. Furthermore, UCP2 is one of the uncoupling protein related to energy consumption/thermogenesis to uncouple oxidative phosphorylation in the mitochondrial inner membrane, and it expresses extensively in organs.

References
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Ucp2
Gene name Uncoupling protein 2
Genotyping information