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Strain Detail: Fcgr1-KO mice

Strain information
Resource No. nbio380
Strain name Fcgr1-KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N
Institution Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition
Developer Osamu Suzuki
Depositor Osamu Suzuki
Conditions of distribution Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

This strain is a knockout strain for the Fcgr1 gene, which encodes one of the subunits composing the receptor protein for the Fc site of the immunoglobulin molecule. Almost all the coding sequence of the Fcgr1 gene on chromosome 3 in C57BL/6N mice was removed with Cas9 proteins and two guide RNAs targeting the starting position of the coding sequence and 3’-UTR of the gene. Because the start codon of Fcgr1 remained in the KO allele, a small irregular peptide (18 AA-long) might be produced, mainly from the 3’-UTR. This strain is useful for the study of acquired immunity.

Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
From other institutions Mating System
Strain status / Availability Cryopreserved sperm
Cryopreserved embryo
Live animals
Gene information
Mutation types knockout
Gene symbol Fcgr1
Gene name Fc receptor, IgG, high affinity I
Genotyping information