HOME > mice > Fcgr1-KO mice
Strain Detail: Fcgr1-KO mice
| Strain information |
| Resource No. |
nbio380 |
| Strain name |
Fcgr1-KO |
| Strain Nomenclature |
|
| Common name/Synonyms |
|
| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Osamu Suzuki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
|
| Strain description |
This strain is a knockout strain for the Fcgr1 gene, which encodes one of the subunits composing the receptor protein for the Fc site of the immunoglobulin molecule. Almost all the coding sequence of the Fcgr1 gene on chromosome 3 in C57BL/6N mice was removed with Cas9 proteins and two guide RNAs targeting the starting position of the coding sequence and 3’-UTR of the gene. Because the start codon of Fcgr1 remained in the KO allele, a small irregular peptide (18 AA-long) might be produced, mainly from the 3’-UTR. This strain is useful for the study of acquired immunity. |
| Reference(s) |
|
| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
|
| Medium |
|
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
|
| Genotype |
|
| Medium |
|
| From other institutions |
Mating System |
|
| Genotype |
|
| Method |
|
| Strain status / Availability |
Cryopreserved sperm |
|
| Cryopreserved embryo |
|
| Live animals |
|
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Fcgr1 |
| Gene name |
Fc receptor, IgG, high affinity I |
| Genotyping information |
|
