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Strain Detail: Fcgr234-KO mice
| Strain information |
| Resource No. |
nbio381 |
| Strain name |
Fcgr234-KO |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Osamu Suzuki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
Mice in which Fcgr2b, Fcgr3, and Fcgr4, which constitute the receptor protein for the Fc site of the immunoglobulin molecule, were knocked out at once. Guide RNAs were set in two places so as to sandwich all three genes, and the nucleotides between them was deleted by genome editing. It is useful for the study of acquired immunity. |
| Reference(s) |
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
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| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
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| Cryopreserved embryo |
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| Live animals |
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| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Fcgr2b, Fcgr3, Fcgr4 |
| Gene name |
[Fc receptor, IgG, low affinity IIb], [Fc receptor, IgG, low affinity III], and [Fc receptor, IgG, low affinity IV] |
| Genotyping information |
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