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Strain Detail
| Strain information | |||
|---|---|---|---|
| Resource No. | nbio014 | ||
| Strain name | GalF | ||
| Strain Nomenclature | |||
| Common name/Synonyms | |||
| Strain types | mutant | ||
| Background strain | C57BL/6NCr Slc |
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| Institution | National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)(formerly, National Institute of Infectious Diseases) | ||
| Developer | Junichiro Matsuda | ||
| Depositor | Junichiro Matsuda | ||
| Conditions of distribution | without conditions : contact us | ||
| Animal Health Report | |||
| Strain description |
GM1-gangliosidosis and Morquio B disease are known as inborn error of metabolism observed different symptom completely, which are caused by genetic defects of lysosomal acid β-galactosidase (β-Gal). The former manifests mainly symptoms of central nervous system, whereas the latter manifests skeletal or cartilaginous symptoms, without nervous symptoms. GalF mice express mutant human β-Gal W273L observed in Morquio B disease. |
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| References | |
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| Resource information | |||
| Cryopreserved sperm | In-house | Genotype | Tg/+ |
| Medium | FERTIUP | ||
| From other institutions | Genotype | ||
| Medium | |||
| Cryopreserved embryo | In-house | Mating System | |
| Genotype | Tg/+ | ||
| Medium | EFS40 | ||
| From other institutions | Mating System | ||
| Genotype | |||
| Medium | |||
| Strain status / Availability | Cryopreserved sperm | Within 1 month | |
| Cryopreserved embryo | Within 1 month | ||
| Live mouse |
Approx. 2 months | ||
| Gene information | |||
| Mutation types | transgenic | ||
| Gene symbol | Glb1 | ||
| Gene name | galactosidase, beta 1 | ||
| Genotyping information | |||