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Strain Detail

Strain information
Resource No. nbio014
Strain name GalF
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6NCr Slc
Institution National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)(formerly, National Institute of Infectious Diseases)
Developer Junichiro Matsuda
Depositor Junichiro Matsuda
Conditions of distribution without conditions : contact us
Animal Health Report
Strain description

GM1-gangliosidosis and Morquio B disease are known as inborn error of metabolism observed different symptom completely, which are caused by genetic defects of lysosomal acid β-galactosidase (β-Gal). The former manifests mainly symptoms of central nervous system, whereas the latter manifests skeletal or cartilaginous symptoms, without nervous symptoms. GalF mice express mutant human β-Gal W273L observed in Morquio B disease.

References
Resource information
Cryopreserved sperm In-house Genotype Tg/+
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype Tg/+
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Glb1
Gene name galactosidase, beta 1
Genotyping information