HOME > mice > GalF mice
Strain Detail
Strain information | |||
---|---|---|---|
Resource No. | nbio014 | ||
Strain name | GalF | ||
Strain Nomenclature | |||
Common name/Synonyms | |||
Strain types | mutant | ||
Background strain | C57BL/6NCr Slc |
||
Institution | National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)(formerly, National Institute of Infectious Diseases) | ||
Developer | Junichiro Matsuda | ||
Depositor | Junichiro Matsuda | ||
Conditions of distribution | without conditions : contact us | ||
Animal Health Report | |||
Strain description |
GM1-gangliosidosis and Morquio B disease are known as inborn error of metabolism observed different symptom completely, which are caused by genetic defects of lysosomal acid β-galactosidase (β-Gal). The former manifests mainly symptoms of central nervous system, whereas the latter manifests skeletal or cartilaginous symptoms, without nervous symptoms. GalF mice express mutant human β-Gal W273L observed in Morquio B disease. |
||
References | |
||
Resource information | |||
Cryopreserved sperm | In-house | Genotype | Tg/+ |
Medium | FERTIUP | ||
From other institutions | Genotype | ||
Medium | |||
Cryopreserved embryo | In-house | Mating System | |
Genotype | Tg/+ | ||
Medium | EFS40 | ||
From other institutions | Mating System | ||
Genotype | |||
Medium | |||
Strain status / Availability | Cryopreserved sperm | Within 1 month | |
Cryopreserved embryo | Within 1 month | ||
Live mouse |
Approx. 2 months | ||
Gene information | |||
Mutation types | transgenic | ||
Gene symbol | Glb1 | ||
Gene name | galactosidase, beta 1 | ||
Genotyping information |