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Strain Detail

Strain information
Resource No. nbio038
Strain name GLUT4-442/E
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Division of basic nutrition, National Institute of Health and Nutrition
Developer
Depositor Shinji Miura
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

GLUT4-442/E mice express transgene included exon and intron of mouse GLUT4 inserted CAT tag in the 3' untranslated region and 442 bp of 5'-upstream region. This strain has two lines, C or E. GLUT4, one of the glucose transporter which is rate-limiting step of importing sugars in muscle or fat tissue, plays an important role of blood sugar homeostasis. This strain is available for diabetes-related research because increasing/decreasing GLUT4 expression level is related to mechanism of onset or preventation of diabetes.

References
  1. Ikemoto S, Thompson KS, Itakura H, Lane MD, and Ezaki O. Expression of an insulin-responsive glucose transporter (GLUT4) minigene in transgenic mice: Effect of exercise and role in glucose homeostasis. Proc. Natl. Acad. Sci. USA, 92(3):865-869 (1995).
  2. Tsunoda N, Cooke DW, Ikemoto S, Maruyama K, Takahashi M, Lane MD, and Ezaki O. Regulated expression of 5′-deleted mouse GLUT4 minigenes in transgenic mice: Effects of exercise training and high-fat diet. Biochem. Biophys. Res. Commun. 239:503-509 (1997).
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Glut4
Gene name Glucose transporter type 4
Genotyping information