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Strain Detail: GLUT4-MEF2/D mice

Strain information
Resource No.	nbio044
Strain name	GLUT4-MEF2/D
Strain Nomenclature
Common name/Synonyms
Strain types	mutant
Background strain
Institution	Division of basic nutrition, National Institute of Health and Nutrition
Developer
Depositor	Shinji Miura
Conditions of distribution	Only for collaboration with the depositor. contact us
Animal Health Report
Strain description	GLUT4-MEF2/D mice express transgene included exon and intron of mouse GLUT4 inserted CAT tag in the 3′-untranslated region and 3,000 bp of 5′-upstream region introduced point mutation in the MEF2 site. This strain has two lines, B or D. GLUT4, one of the glucose transporter which is rate-limiting step of importing sugars in muscle or fat tissue, plays an important role of blood sugar homeostasis. This strain is available for diabetes-related research because increasing/decreasing GLUT4 expression level is related to mechanism of onset or preventation of diabetes.
Reference(s)	Ikemoto S, Thompson KS, Itakura H, Lane MD, and Ezaki O. (1995) Expression of an insulin-responsive glucose transporter (GLUT4) minigene in transgenic mice: effect of exercise and role in glucose homeostasis. Proc. Natl. Acad. Sci. U.S.A. 92(3):865-9. [PMID:7846068] Tsunoda N, Cooke DW, Ikemoto S, Maruyama K, Takahashi M, Lane MD, and Ezaki O. (1997) Regulated expression of 5′-deleted mouse GLUT4 minigenes in transgenic mice: effects of exercise training and high-fat diet. Biochem. Biophys. Res. Commun. 239(2):503-9. [PMID:9344860]

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