Strain Detail: GLUT4-Mut701 mice

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GLUT4-Mut701 mice express transgene included exon and intron of mouse GLUT4 inserted CAT tag in the 3' untranslated region and 701 bp of 5'-upstream region introduced point mutation in part. This strain is available for analysis of GLUT4 promoter. GLUT4, one of the glucose transporter which is rate-limiting step of importing sugars in muscle or fat tissue, plays an important role of blood sugar homeostasis. This strain is available for diabetes-related research because increasing/decreasing GLUT4 expression level is related to mechanism of onset or preventation of diabetes.

1. Ikemoto S, Thompson KS, Itakura H, Lane MD, and Ezaki O. Expression of an insulin-responsive glucose transporter (GLUT4) minigene in transgenic mice: Effect of exercise and role in glucose homeostasis.Proc. Natl. Acad. Sci. USA, 92, 865-869 (1995). [PMID: 7846068]
2. Tsunoda N, Cooke DW, Ikemoto S, Maruyama K, Takahashi M, Lane MD, and Ezaki O. Regulated expression of 5′-deleted mouse GLUT4 minigenes in transgenic mice: effects of exercise training and high-fat diet.Biochem. Biophys. Res. Commun. 239, 503-509 (1997). [PMID: 9344860]