HOME > mice > GLUT4-NF1/A mice
Strain Detail
Strain information | |||
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Resource No. | nbio079 | ||
Strain name | GLUT4-NF1/A | ||
Strain Nomenclature | |||
Common name/Synonyms | |||
Strain types | mutant | ||
Background strain | |||
Institution | Division of basic nutrition, National Institute of Health and Nutrition | ||
Developer | Shinji Miura | ||
Depositor | Shinji Miura |
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Conditions of distribution | It's necessary to obtain depositor's consent on use of biological resources. : contact us | ||
Animal Health Report | |||
Strain description |
GLUT4-NF1/A mice express transgene included exon and intron of mouse GLUT4 inserted CAT tag in the 3' untranslated region and 3,000 bp of 5'-upstream region introduced point mutation in the NF1 site. This strain is available for analysis of GLUT4 promoter. This strain has 4 lines, A, B, D-L, D-H. GLUT4, one of the glucose transporter which is rate-limiting step of importing sugars in muscle or fat tissue, plays an important role of blood sugar homeostasis. This strain is available for diabetes-related research because increasing/decreasing GLUT4 expression level is related to mechanism of onset or preventation of diabetes. |
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References |
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Resource information | |||
Cryopreserved sperm | In-house | Genotype | |
Medium | FERTIUP | ||
From other institutions | Genotype | ||
Medium | |||
Cryopreserved embryo | In-house | Mating System | |
Genotype | |||
Medium | EFS40 | ||
From other institutions | Mating System | ||
Genotype | |||
Medium | |||
Strain status / Availability | Cryopreserved sperm | Within 1 month | |
Cryopreserved embryo | Within 1 month | ||
Live mouse |
Approx. 2 months | ||
Gene information | |||
Mutation types | transgenic | ||
Gene symbol | Glut4 | ||
Gene name | Glucose transporter type 4 | ||
Genotyping information |