HOME > mice > Invs-KO mice
Strain Detail: Invs-KO mice
| Strain information |
| Resource No. |
nbio463 |
| Strain name |
Invs-KO |
| Strain Nomenclature |
|
| Common name/Synonyms |
|
| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Osamu Suzuki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
|
| Strain description |
Nephronophthisis (NPH) is a disease in which cyst formation is observed in the renal medulla, and the responsible genes for NPHP1 to NPHP16 have been identified. Among them, NPHP2, the gene responsible for infantile nephropathy (NPH2), contains Invs, which is involved in left-right axis determination and cyst formation. This strain lacks exon 5 of the Invs gene by genome editing and is useful for studying left-right axis formation and morphogenesis of organs such as liver and kidney (e.g., cystic kidney). |
| Reference(s) |
|
| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
Heterozygous |
| Medium |
Fertiup |
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
|
| Genotype |
|
| Medium |
|
| From other institutions |
Mating System |
|
| Genotype |
|
| Method |
|
| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
|
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Invs |
| Gene name |
Inversion |
| Genotyping information |
|
