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Strain Detail

Strain information
Resource No. nbio174
Strain name IRD1
Strain Nomenclature
Common name/Synonyms ICR-derived retinal dysfunction 1 mice
Strain types outbred
Background strain
Institution Takeda Pharmaceutical Co., Ltd.
Developer Makoto Miyamoto
Depositor Makoto Miyamoto
Conditions of distribution In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1,2,3) designated by the depositor is requested. The recipient agrees that LARB informs the depositor of recipient organization, recipient name and the specific research purpose. : contact us
Animal Health Report
Strain description

IRD1 mice become spontaneous inheritable rod and cone dysfunction, and they are observed late-onset progressive retinal degeneration. It's considered that the cause of rod dysfunction is the deletion of Trα protein caused by nonsense mutation of Gnat1 gene. The cause of cone dysfunction is unknown. It's considered that this strain is useful for the research of inheritable retinal disease. This strain is derived from Crj:CD-1(ICR). It's possible to supply IRD2 mice observed only rod dysfunction.

References
  1. Miyamoto M, Aoki M, Sugimoto S, Kawasaki K, Imai R. IRD1 and IRD2 mice, naturally occurring models of hereditary retinal dysfunction, show late-onset and progressive retinal degeneration. Curr Eye Res. 2010 Feb;35(2):137-45.PMID: 20136424
  2. Miyamoto M, Aoki M, Hirai K, Sugimoto S, Kawasaki K, Imai R. A nonsense mutation in Gnat1, encoding the alpha subunit of rod transducin, in spontaneous mouse models of retinal dysfunction. Exp Eye Res. 2010 Jan;90(1):63-9. Epub 2009 Sep 17. PMID: 19766629
  3. Miyamoto M, Imai R, Sugimoto S, Aoki M, Nagai H, Ando T. Visual electrophysiological features of two naturally occurring mouse models with retinal dysfunction. Curr Eye Res. 2006 Apr;31(4):329-35. PMID: 16603466
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types spontaneus mutation
Gene symbol Gnat1
Gene name Guanine nucleotide binding protein, alpha transducing 1
Genotyping information