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Strain Detail: L-PGDS-H-PGDS-dKO mice

Strain information
Resource No. nbio424
Strain name L-PGDS-H-PGDS-dKO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6J
Institution Center for Supporting Pharmaceutical Education, Daiichi University of Pharmacy
Developer Yoshihiro Urade
Depositor Yoshihiro Urade
Conditions of distribution The user must cite the reference (Ref. 1) provided by the depositors when publishing the research results. contact us
Animal Health Report
Strain description

The double knockout mice lack both lipocalin-type PGD synthase and hematopoietic-type PGD synthase.

  1. Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M, and Urade Y. (2014) Prostaglandin D(2) is crucial for seizure suppression and postictal sleep. Exp Neurol 253():82-90. [PMID:24333565]
Resource information
Cryopreserved sperm In-house Genotype DKO
Medium Fertiup
From other institutions Genotype
Cryopreserved embryo In-house Mating System homozygous sperm x C57BL/6J Jcl, & homozygous sperm x heterozygous
Genotype heterozygous & homozygous
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types dobule knockout
Gene symbol Ptgds (L-PGDS), Hpgds
Gene name prostaglandin D2 synthase (brain), hematopoietic prostaglandin D synthase
Genotyping information