HOME > mice > LECT2-KO (BALB/cAJcl) mice

Strain Detail

Strain information
Resource No. nbio176
Strain name LECT2-KO (BALB/cAJcl)
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases
Developer Satoshi Yamagoe
Depositor Satoshi Yamagoe
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources.
Only for collaboration with the depositor : contact us
Animal Health Report
Strain description

Leukocyte cell-derived chemotaxin 2 (LECT2) is a cytokine found as neutrophil chemotactic factor and a 16 kDa protein specifically expressing in liver parenchymal cells. It's considered that LECT2 is related to various disease such as hepatic dysfunction or rheumatoid arthritis. Two lines of LECT2 KO mice to have different gene background, BALB/cAJcl or C57BL/6JJcl, are available. In the reference, it's suggested that IL-4 overproduction of LECT2 KO mice affected with con A-induced hepatitis is caused by increase of NKT cells and it causes of severe hepatic dysfunction. It's also considered that LECT2 suppresses the homeostasis of NKT cells in the liver because of specifically NKT cells increase in the liver.

References
  1. Saito T, Okumura A, Watanabe H, Asano M, Ishida-Okawara A, Sakagami J, Sudo K, Hatano-Yokoe Y, Bezbradica JS, Joyce S, Abo T, Iwakura Y, Suzuki K, Yamagoe S. Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin 2-deficient mice contributes to severe concanavalin A-induced hepatitis. J Immunol. 2004 Jul 1;173(1):579-85. PMID: 15210819
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
 Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Lect2
Gene name Leukocyte cell-derived chemotaxin 2
Genotyping information Genotyping protocol for LECT2-KO mice (pdf).