HOME > mice > LECT2-KO (BALB/cAJcl) mice
Strain Detail
Strain information | |||
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Resource No. | nbio176 | ||
Strain name | LECT2-KO (BALB/cAJcl) | ||
Strain Nomenclature | |||
Common name/Synonyms | |||
Strain types | mutant | ||
Background strain | |||
Institution | Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases |
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Developer | Satoshi Yamagoe |
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Depositor | Satoshi Yamagoe | ||
Conditions of distribution | It's necessary to obtain depositor's consent on use of biological resources. Only for collaboration with the depositor : contact us |
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Animal Health Report | |||
Strain description |
Leukocyte cell-derived chemotaxin 2 (LECT2) is a cytokine found as neutrophil chemotactic factor and a 16 kDa protein specifically expressing in liver parenchymal cells. It's considered that LECT2 is related to various disease such as hepatic dysfunction or rheumatoid arthritis. Two lines of LECT2 KO mice to have different gene background, BALB/cAJcl or C57BL/6JJcl, are available. In the reference, it's suggested that IL-4 overproduction of LECT2 KO mice affected with con A-induced hepatitis is caused by increase of NKT cells and it causes of severe hepatic dysfunction. It's also considered that LECT2 suppresses the homeostasis of NKT cells in the liver because of specifically NKT cells increase in the liver. |
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References |
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Resource information | |||
Cryopreserved sperm | In-house | Genotype | |
Medium | FERTIUP | ||
From other institutions | Genotype | ||
Medium | |||
Cryopreserved embryo | In-house | Mating System | |
Genotype | |||
Medium | EFS40 | ||
From other institutions | Mating System | ||
Genotype | |||
Medium | |||
Strain status / Availability | Cryopreserved sperm | Within 1 month | |
Cryopreserved embryo | Within 1 month | ||
Live mouse |
Approx. 2 months | ||
Gene information | |||
Mutation types | knockout | ||
Gene symbol | Lect2 | ||
Gene name | Leukocyte cell-derived chemotaxin 2 | ||
Genotyping information | Genotyping protocol for LECT2-KO mice (pdf). |