HOME > mice > LECT2-Tg12 (BALB/cAJcl) mice
Strain Detail: LECT2-Tg12 (BALB/cAJcl) mice
| Strain information |
| Resource No. |
nbio178 |
| Strain name |
LECT2-Tg12 (BALB/cAJcl) |
| Strain Nomenclature |
|
| Common name/Synonyms |
|
| Strain types |
mutant |
| Background strain |
|
| Institution |
Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases |
| Developer |
Satoshi Yamagoe |
| Depositor |
Satoshi Yamagoe |
| Conditions of distribution |
without conditions: contact us |
| Animal Health Report |
|
| Strain description |
Leukocyte cell-derived chemotaxin 2 (LECT2) is a cytokine found as neutrophil chemotactic factor and a 16 kDa protein specifically expressing in liver parenchymal cells. It's considered that LECT2 is related to various disease such as hepatic dysfunction or rheumatoid arthritis. LECT2-Tg mice express mouse LECT2 under the control of CAG promoter in whole body. This strain has two lines, 12 or 33, and each line has different gene background, BALB/cAJcl or C57BL/6JJcl. Therefore, 4 types of LECT2-Tg mice are available. Especially, line 33 is ten to hundred times LECT2 concentration in blood compared with wildtype. This strain is useful for the elucidation of in vivo function of LECT2. |
| Reference(s) |
|
| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
|
| Medium |
FERTIUP |
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
|
| Genotype |
|
| Medium |
EFS40 |
| From other institutions |
Mating System |
|
| Genotype |
|
| Method |
|
| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Lect2 |
| Gene name |
Leukocyte cell-derived chemotaxin 2 |
| Genotyping information |
|
