HOME > mice > Col11a2-hSIK3tg mice
Strain Detail: Col11a2-hSIK3tg mice
| Strain information |
| Resource No. |
nbio233 |
| Strain name |
Col11a2-hSIK3tg |
| Strain Nomenclature |
|
| Common name/Synonyms |
LI-hSIK3tg |
| Strain types |
mutant |
| Background strain |
|
| Institution |
Center for iPS Cell Research and Application, Kyoto-University |
| Developer |
Noriyuki Tsumaki |
| Depositor |
Noriyuki Tsumaki |
| Conditions of distribution |
It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
|
| Strain description |
This strain is specifically expressing human SIK3 under the control of col11a2 promoter/enhancer in cartilage. These mice are closed growth plate earlier after birth. Incidentally, this strain is able to rescue the phenotype of fetal cartilage in SIK3 knockout mouse. |
| Reference(s) |
- Sasagawa S, Takemori H, Uebi T, Ikegami D, Hiramatsu K, Ikegawa S, Yoshikawa H, and Tsumaki N. (2012) SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice. Development 139(6):1153-63. [PMID:22318228]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
|
| Medium |
FERTIUP |
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
|
| Genotype |
|
| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
|
| Method |
|
| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
transgenic |
| Gene symbol |
SIK3 |
| Gene name |
SIK family kinase 3 |
| Genotyping information |
|
