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Strain Detail: Col11a2-hSIK3tg mice

Strain information
Resource No. nbio233
Strain name Col11a2-hSIK3tg
Strain Nomenclature
Common name/Synonyms LI-hSIK3tg
Strain types mutant
Background strain
Institution Center for iPS Cell Research and Application, Kyoto-University
Developer Noriyuki Tsumaki
Depositor Noriyuki Tsumaki
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

This strain is specifically expressing human SIK3 under the control of col11a2 promoter/enhancer in cartilage. These mice are closed growth plate earlier after birth. Incidentally, this strain is able to rescue the phenotype of fetal cartilage in SIK3 knockout mouse.

  1. Sasagawa S, Takemori H, Uebi T, Ikegami D, Hiramatsu K, Ikegawa S, Yoshikawa H, and Tsumaki N. (2012) SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice. Development 139(6):1153-63. [PMID:22318228]
Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol SIK3
Gene name SIK family kinase 3
Genotyping information