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Strain Detail: MacATF3 Tg #25 mice

Strain information
Resource No. nbio136
Strain name MacATF3 Tg #25
Strain Nomenclature
Common name/Synonyms Microphage-specific ATF3 transgenic mouse #25
Strain types mutant
Background strain
Institution Medical Research Institute, Tokyo Medical and Dental University
Developer Yoshihiro Ogawa
Depositor Yoshihiro Ogawa
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

MacATF3 Tg #25 mice specifically overexpress human ATF3 (activating transcription factor-3) which is a basic-leucine zipper transcription factor to belong to ATF/CREB family under the control of human scavenger receptor A (SR-A) promoter in macrophages. These mice decrease inflammatory cytokine production level of macrophages in obese adipose tissues and suppress the macrophage activation compared with control wildtype mice. This strain is available for pathophysiological elucidation of inflammatory change in adipose tissues of obesity or metabolic syndrome. This strain has two lines, #25 or#35, and the former is three times ATF3 protein level in macrophages compared with wildtype whereas the latter is twice it.

  1. Suganami T, Yuan X, Shimoda Y, Uchio-Yamada K, Nakagawa N, Shirakawa I, Usami T, Tsukahara T, Nakayama K, Miyamoto Y, Yasuda K, Matsuda J, Kamei Y, Kitajima S, Ogawa Y. Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated Fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue. Circ Res. 2009 Jul 2;105(1):25-32. [PMID: 19478204]
Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Atf3 (LRG-21)
Gene name Activating transcription factor 3
Genotyping information