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Strain Detail: MEF2A mice
| Strain information | |
|---|---|
| Resource No. | nbio059 |
| Strain name | MEF2A |
| Strain Nomenclature | |
| Common name/Synonyms | |
| Strain types | mutant |
| Background strain | |
| Institution | Division of basic nutrition, National Institute of Health and Nutrition |
| Developer | |
| Depositor | Shinji Miura |
| Conditions of distribution | Only for collaboration with the depositor. contact us |
| Animal Health Report | |
| Strain description | MEF2A mice overexpress MEF2A specifically in skeletal muscle. It's reported that MEF2A is one of the transcription factor promoting shift in redskeletalmuscle. It's also reported that MEF2A involves expression of GLUT4 which plays an important role in importing sugar in the muscle. Red-shifted skeletal muscle promotes fatty acid oxidation and up-regulation of GLUT4 activates carbohydrate metabolism. Thus, it's assumed that MEF2A mice are available for resolution of preventive mechanism of diabetes or metabolic syndrome to target MEF2A. |
| Reference(s) | |
| Resource information | |||
|---|---|---|---|
| Cryopreserved sperm | In-house | Genotype | |
| Medium | FERTIUP | ||
| From other institutions | Genotype | ||
| Medium | |||
| Cryopreserved embryo | In-house | Mating System | |
| Genotype | |||
| Medium | EFS40 | ||
| From other institutions | Mating System | ||
| Genotype | |||
| Method | |||
| Strain status / Availability | Cryopreserved sperm | Within 1 month | |
| Cryopreserved embryo | Within 1 month | ||
| Live animals | Approx. 2 months | ||
| Gene information | |
|---|---|
| Mutation types | transgenic |
| Gene symbol | Mef2a |
| Gene name | Myocyte enhancer factor 2A |
| Genotyping information | |