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Strain Detail

Strain information
Resource No. nbio059
Strain name MEF2A
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Division of basic nutrition, National Institute of Health and Nutrition
Developer
Depositor Shinji Miura
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

MEF2A mice overexpress MEF2A specifically in skeletal muscle. It's reported that MEF2A is one of the transcription factor promoting shift in red skeletal muscle. It's also reported that MEF2A involves expression of GLUT4 which plays an important role in importing sugar in the muscle. Red-shifted skeletal muscle promotes fatty acid oxidation and up-regulation of GLUT4 activates carbohydrate metabolism. Thus, it's assumed that MEF2A mice are available for resolution of preventive mechanism of diabetes or metabolic syndrome to target MEF2A.

References
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Mef2a
Gene name Myocyte enhancer factor 2A
Genotyping information