HOME > mice > Meg1 Tg/T18L mice
Strain Detail: Meg1 Tg/T18L mice
| Strain information |
| Resource No. |
nbio115 |
| Strain name |
Meg1 Tg/T18L |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
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| Institution |
Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University1,Tokai University School of Health Sciences2 |
| Developer |
Fumitoshi Ishino1, Tomoko Kaneko-Ishino2 |
| Depositor |
Fumitoshi Ishino1, Tomoko Kaneko-Ishino2 |
| Conditions of distribution |
It's necessary to obtain depositor's consent on use ofbiologicalresources. contact us |
| Animal Health Report |
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| Strain description |
Meg1 Tg/T18L mice are transgenic mice overexpressing mouse Meg1/Grb10 in whole body. Meg1/Grb10 is an imprinting gene to express from only maternal genome. CAG promoter is used for transgene expression. This strain shows poor growth after weaning and insulin resistance, then onset of diabetes. Furthermore, this strain increases diabetes incidence rate by high nutritional feed. This strain is type 2 diabetes model mice. These mice become polyuria with onset of diabetes, therefore it's necessary to change mouse bedding frequently. This strain has different 4 lines from expression level. |
| Reference(s) |
- Shiura H, Miyoshi N, Konishi A, Wakisaka-Saito N, Suzuki R, Muguruma K, Kohda T, Wakana S, Yokoyama M, Ishino F, and Kaneko-Ishino T. (2005) Meg1/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1R and IR cascades. Biochem. Biophys. Res. Commun. 329(3):909-16. [PMID:15752742]
- Yamamoto Y, Ishino F, Kaneko-Ishino T, Shiura H, Uchio-Yamada K, Matsuda J, Suzuki O, and Sato K. (2008) Type 2 diabetes mellitus in a non-obese mouse model induced by Meg1/Grb10 overexpression. Exp. Anim. 57(4):385-95. [PMID:18633161]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
FERTIUP |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
transgenic |
| Gene symbol |
Meg1 (Grb10) |
| Gene name |
Meiosis expressed gene 1 (Growth factor receptor-bound protein 10) |
| Genotyping information |
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