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Strain Detail: miErbB3 Tg

Strain information
Resource No. nbio259
Strain name miErbB3 Tg
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6J Jms
Institution Department of Pharmacology and Laboratory Animal Resource Facility, National Research Institute for Child Health and Development
Developer Junji Yamauchi, Tomohiro Torii
Depositor Junji Yamauchi, Tomohiro Torii
Conditions of distribution

In publishing the research results obtained by use of the animal resource, a citation of the following literature (ref.1) and the stipulation of an acknowledgment to depositor designated by the depositor is requested. It's necessary to obtain depositor's consent on use of biological resources. Only for collaboration with the depositor : contact us

Animal Health Report
Strain description

The miErbB3 Tg mice are transgenic mice with in vivo knockdown of ErbB3 using a Schwann-cell-specific-promoter-driven production of ErbB3 specific shRNA. Knockdown of ErbB3 using a Schwann cell-specific promoter in mice causes delayed migration of Schwann cell precursors and also reduces myelin thickness in sciatic nerves. The strain is useful for research on the peripheral nerve development.

References
  1. Torii T, Miyamoto Y, Takada S, Tsumura H, Arai M, Nakamura K, Ohbuchi K, Yamamoto M, Tanoue A, Yamauchi J. In vivo knockdown of ErbB3 in mice inhibits Schwann cell precursor migration. Biochem Biophys Res Commun. 2014, 452(3):782-8. doi: 10.1016/j.bbrc.2014.08.156.
Resource information
Cryopreserved sperm In-house Genotype Tg/+
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System IVF
Genotype mix of Tg/+ and wild-type
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Erbb3
Gene name v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Genotyping information