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Strain Detail: MUSCLE-UCP3 mice
| Strain information |
| Resource No. |
nbio111 |
| Strain name |
MUSCLE-UCP3 |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
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| Institution |
Division of basic nutrition, National Institute of Health and Nutrition |
| Developer |
Nobuyo Kasaoka |
| Depositor |
Nobuyo Kasaoka |
| Conditions of distribution |
It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
MUSCLE-UCP3 mice are transgenic mice specifically overexpressing human UCP3 in skeletal muscle. This strain expects to be suppressed fat accumulation, therefore it's available for the research of prevention and therapy for human obesity and diabetes. Mouse myosin light chain promoter is used for transgene expression. These mice overexpress 1.5 times human UCP3 compared with normal mice. Futhermore, UCP3 is one of the uncoupling protein related to energy consumption/thermogenesis to uncouple oxidative phosphorylation in the mitochondrial inner membrane, and it expresses mainly in skeletal muscle. |
| Reference(s) |
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
FERTIUP |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
transgenic |
| Gene symbol |
Ucp3 |
| Gene name |
Uncoupling protein 3 |
| Genotyping information |
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