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Strain Detail: MUSCLE-UCP3 mice

Strain information
Resource No. nbio111
Strain name MUSCLE-UCP3
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Division of basic nutrition, National Institute of Health and Nutrition
Developer Nobuyo Kasaoka
Depositor Nobuyo Kasaoka
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

MUSCLE-UCP3 mice are transgenic mice specifically overexpressing human UCP3 in skeletal muscle. This strain expects to be suppressed fat accumulation, therefore it's available for the research of prevention and therapy for human obesity and diabetes. Mouse myosin light chain promoter is used for transgene expression. These mice overexpress 1.5 times human UCP3 compared with normal mice. Futhermore, UCP3 is one of the uncoupling protein related to energy consumption/thermogenesis to uncouple oxidative phosphorylation in the mitochondrial inner membrane, and it expresses mainly in skeletal muscle.

Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Ucp3
Gene name Uncoupling protein 3
Genotyping information