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Strain Detail

Strain information
Resource No. nbio229
Strain name NDRG4 KO
Strain Nomenclature C57BL/6J-Ndrg4tmNCVC
Common name/Synonyms
Strain types mutant
Background strain
Institution Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute
Developer Toshiyuki Miyata
Depositor Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1) designated by the depositor is requested. It's necessary to obtain depositor's consent on use of biological resources.: contact us
Animal Health Report
Strain description

NDRG4 KO mice are knockout mice of Ndrg4 gene. These mice are born normally according to Mendelian inheritance, but they will decrease brain-derived neurotrophic factor (BDNF) in cerebral cortices. Consequently, these mice shows disorders of spatial learning or spatial memory and the reduction of resistance for neuronal death caused by cerebral ischemia.

References
  1. Yamamoto H, Kokame K, Okuda T, Nakajo Y, Yanamoto H, Miyata T. NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia. J Biol Chem. 2011 Jul 22;286(29):26158-65. doi: 10.1074/jbc.M111.256446. Epub 2011 Jun 2.
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Ndrg4
Gene name NDRG family member 4
Genotyping information