HOME > mice > PGC-1α/D mice
Strain Detail
Strain information | |||
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Resource No. | nbio096 |
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Strain name | PGC-1α/D | ||
Strain Nomenclature | |||
Common name/Synonyms | |||
Strain types | mutant | ||
Background strain | |||
Institution | Division of basic nutrition, National Institute of Health and Nutrition | ||
Developer | Shinji Miura | ||
Depositor | Shinji Miura |
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Conditions of distribution | It's necessary to obtain depositor's consent on use of biological resources. : contact us | ||
Animal Health Report | |||
Strain description |
PGC-1α/D mice are transgenic mice specifically overexpressing PGC-1α (peroxisome proliferator-activated receptor γ coactivator-1α) in skeletal muscle. This strain expresses 2.4 kb cDNA encoding mouse PGC-1α under the control of human α actin promoter on -2,000 bp. This strain observes shift in red skeletal muscle and increase of mitochondrial number, then becomes muscle atrophy at 25 weeks of age. This strain has three lines. It's known that PGC-1α, a cofactor of nuclear receptor PPARγ, promotes mitochondria synthesis. It's considered that this strain is a model mouse of the Luft's disease, one of the mitochondrial myopathy. |
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References |
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Resource information | |||
Cryopreserved sperm | In-house | Genotype | |
Medium | FERTIUP | ||
From other institutions | Genotype | ||
Medium | |||
Cryopreserved embryo | In-house | Mating System | |
Genotype | |||
Medium | EFS40 | ||
From other institutions | Mating System | ||
Genotype | |||
Medium | |||
Strain status / Availability | Cryopreserved sperm | Within 1 month | |
Cryopreserved embryo | Within 1 month | ||
Live mouse |
Approx. 2 months | ||
Gene information | |||
Mutation types | transgenic | ||
Gene symbol | Ppargc1a (PGC-1α) | ||
Gene name | Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | ||
Genotyping information |