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Strain Detail: PGC-1α/D mice

Strain information
Resource No. nbio096
Strain name PGC-1α/D
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Division of basic nutrition, National Institute of Health and Nutrition
Developer Shinji Miura
Depositor Shinji Miura
Conditions of distribution

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Animal Health Report
Strain description

PGC-1α/D mice are transgenic mice specifically overexpressing PGC-1α (peroxisome proliferator-activated receptor γ coactivator-1α) in skeletal muscle. This strain expresses 2.4 kb cDNA encoding mouse PGC-1α under the control of human α actin promoter on -2,000 bp. This strain observes shift in red skeletal muscle and increase of mitochondrial number, then becomes muscle atrophy at 25 weeks of age. This strain has three lines. It's known that PGC-1α, a cofactor of nuclear receptor PPARγ, promotes mitochondria synthesis.

It's considered that this strain is a model mouse of the Luft's disease, one of the mitochondrial myopathy.
Reference(s)
  1. Miura S, Kai Y, Ono M, and Ezaki O. (2003) Overexpression of peroxisome proliferator-activated receptor γ coactivator-1α down-regulates GLUT4 mRNA in skeletal muscles. J. Biol. Chem. 278(33):31385-90. [PMID:12777397]
  2. Miura S, Tomitsuka E, Kamei Y, Yamazaki T, Kai Y, Tamura M, Kita K, Nishino I, and Ezaki O. (2006) Overexpression of peroxisome proliferator-activated receptor γ co-activator-1α leads to muscle atrophy with depletion of ATP. Am. J. Pathol. 169(4):1129-39. [PMID:17003473]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Ppargc1a (PGC-1α)
Gene name Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Genotyping information