HOME > mice > Rgs16 knockdown mouse line#53

Strain Detail

Strain information
Resource No. nbio182
Strain name Rgs16 knockdown mouse line#53
Strain Nomenclature
Common name/Synonyms Rgs16 KD-line#53
Strain types mutant
Background strain C57BL/6JJcl
Institution Kinki University School of Medicine
Developer Naoto Hayasaka
Depositor Naoto Hayasaka
Conditions of distribution In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1) designated by the depositor is requested. It's necessary to obtain depositor's consent on use of biological resources.: contact us
Animal Health Report
Strain description

Rgs16 knockdown mouse line#53 decreases expression of Rgs16, which is a member of regulators of G protein Signaling (RGS) family. This mouse is transgenic mouse generated to use lentiviral vector expressing Rgs16 mRNA targeted shRNA. This strain shows to change the cycle of locomotor activity rhythms and reduce total activity level, furthermore reduce food anticipatory activity (FAA) in the scheduled feeding. It's considered that this strain is useful model of anomaly of circadian locomotor rhythms. Gene background is C57BL/6JJcl.

References
  1. Hayasaka N, Aoki K, Kinoshita S, Yamaguchi S, Wakefield JK, Tsuji-Kawahara S, Horikawa K, Ikegami H, Wakana S, Murakami T, Ramabhadran R, Miyazawa M, Shibata S. Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in rgs16 knockdown mice. PLoS One. 2011 Mar 9;6(3):e17655. PMID: 21408016
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Rgs16
Gene name Regulator of G-protein signaling 16
Genotyping information