HOME > mice > FVB/N-Tg(L7ATTCT160)Bay mice
Strain Detail
| Strain information | |||
|---|---|---|---|
| Resource No. | nbio203 | ||
| Strain name | FVB/N-Tg(L7ATTCT160)Bay | ||
| Strain Nomenclature | FVB/N-Tg(L7ATTCT160)Bay | ||
| Common name/Synonyms | SCA10 | ||
| Strain types | mutant | ||
| Background strain | |||
| Institution | Baylor College of Medicine | ||
| Developer | |
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| Depositor | Tohru Matsuura (Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University) | ||
| Conditions of distribution | In publishing the research results obtained by use of the animal resource, the stipulation of an acknowledgment to depositor designated by the depositor is requested. : contact us | ||
| Animal Health Report | |||
| Strain description |
This strain is a model mouse for the analysis of spinocerebellar ataxia type 10 (SCA10), which is an incurable disease. SCA10 is a dominantly-inherited neurodegenerative disease whose cardinal signs are cerebellar ataxia and epilepsy, and clinical symptoms are rich in diversity. SCA10 is caused by unstable abnormal elongation of ATTCT repeats in intron 9 of ATXN10 gene and it's only hexanucleotide repeat disease for human. This strain is a transgenic mouse expressing 160 ATTCT repeats under the control of murine L7 promoter. Incidenntally, this strain is used modified L7-GFP (ref.1) and inserted ATTCT repeats in intron 3. |
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| Resource information | |||
| Cryopreserved sperm | In-house | Genotype | |
| Medium | |||
| From other institutions | Genotype | ||
| Medium | |||
| Cryopreserved embryo | In-house | Mating System | |
| Genotype | |||
| Medium | |||
| From other institutions | Mating System | ||
| Genotype | |||
| Medium | |||
| Strain status / Availability | Cryopreserved sperm | Within 1 month | |
| Cryopreserved embryo | Within 1 month | ||
| Live mouse |
Approx. 2 months | ||
| Gene information | |||
| Mutation types | transgenic | ||
| Gene symbol | Atxn10, Pcp2, GFP | ||
| Gene name | ataxin 10, Purkinje cell protein 2, Green fluorescent protein | ||
| Genotyping information | |||