HOME > mice > FVB/N-Tg(L7ATTCT21)Bay mice

Strain Detail

Strain information
Resource No. nbio204
Strain name FVB/N-Tg(L7ATTCT21)Bay
Strain Nomenclature FVB/N-Tg(L7ATTCT21)Bay
Common name/Synonyms SCA10
Strain types mutant
Background strain
Institution Baylor College of Medicine
Developer
Depositor Tohru Matsuura (Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University)
Conditions of distribution In publishing the research results obtained by use of the animal resource, the stipulation of an acknowledgment to depositor designated by the depositor is requested. : contact us
Animal Health Report
Strain description

This strain is a model mouse for the analysis of spinocerebellar ataxia type 10 (SCA10), which is an incurable disease. SCA10 is a dominantly-inherited neurodegenerative disease whose cardinal signs are cerebellar ataxia and epilepsy, and clinical symptoms are rich in diversity. SCA10 is caused by unstable abnormal elongation of ATTCT repeats in intron 9 of ATXN10 gene and it's only hexanucleotide repeat disease for human. This strain is a transgenic mouse expressing 21 ATTCT repeats under the control of murine L7 promoter. Incidenntally, this strain is used modified L7-GFP (ref.1) and inserted ATTCT repeats in intron 3.

References
  1. Tomomura M, Rice DS, Morgan JI, Yuzaki M. Purification of Purkinje cells by fluorescence-activated cell sorting from transgenic mice that express green fluorescent protein. Eur J Neurosci. 2001 Jul;14(1):57-63.
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Atxn10, Pcp2, GFP
Gene name ataxin 10, Purkinje cell protein 2, Green fluorescent protein
Genotyping information