HOME > mice > FVB/N-Tg(L7ATTCT21)Bay mice
Strain Detail: FVB/N-Tg(L7ATTCT21)Bay mice
| Strain information |
| Resource No. |
nbio204 |
| Strain name |
FVB/N-Tg(L7ATTCT21)Bay |
| Strain Nomenclature |
FVB/N-Tg(L7ATTCT21)Bay |
| Common name/Synonyms |
SCA10 |
| Strain types |
mutant |
| Background strain |
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| Institution |
Baylor College of Medicine |
| Developer |
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| Depositor |
Tohru Matsuura (Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University) |
| Conditions of distribution |
In publishing the research results obtained by use of the animal resource, the stipulation of an acknowledgment to depositor designated by the depositor is requested. :contact us |
| Animal Health Report |
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| Strain description |
This strain is a model mouse for the analysis of spinocerebellar ataxia type 10 (SCA10), which is an incurable disease. SCA10 is a dominantly-inherited neurodegenerative disease whose cardinal signs are cerebellar ataxia and epilepsy, and clinical symptoms are rich in diversity. SCA10 is caused by unstable abnormal elongation of ATTCT repeats in intron 9 of ATXN10 gene and it's only hexanucleotide repeat disease for human. This strain is a transgenic mouse expressing 21 ATTCT repeats under the control of murine L7 promoter. Incidenntally, this strain is used modified L7-GFP (ref.1) and inserted ATTCT repeats in intron 3. |
| Reference(s) |
- Tomomura M, Rice DS, Morgan JI, and Yuzaki M. (2001) Purification of Purkinje cells by fluorescence-activated cell sorting from transgenic mice that express green fluorescent protein. Eur J Neurosci 14(1):57-63. [PMID:11488949]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
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| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
transgenic |
| Gene symbol |
Atxn10, Pcp2, GFP |
| Gene name |
ataxin 10, Purkinje cell protein 2, Green fluorescent protein |
| Genotyping information |
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