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Strain Detail: Sftpd-KO mice

Strain information
Resource No. nbio386
Strain name Sftpd-KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N
Institution Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition
Developer Mitsuho Sasaki
Depositor Osamu Suzuki
Conditions of distribution Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

Knockout mice of surfactant associated protein D (SFTPD), one of the pulmonary surfactant proteins. They were created by introducing a deletion of 11 bp into Exon 2 of the Sftpd gene by genome editing. SFTPD functions as a surfactant that relieves surface tension in the alveoli and is responsible for innate immunity in the alveoli. It is expected to be used as a model for pulmonary fibrosis.

Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
From other institutions Mating System
Strain status / Availability Cryopreserved sperm
Cryopreserved embryo
Live animals
Gene information
Mutation types knockout
Gene symbol Sftpd
Gene name surfactant associated protein D
Genotyping information