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Strain Detail: SOCS-5 Tg/line5-1 mice

Strain information
Resource No. nbio072
Strain name SOCS-5 Tg/line5-1
Strain Nomenclature
Common name/Synonyms β-actin-SOCS-5 transgenic mouse (line5-1)
Strain types mutant
Background strain
Institution Faculty of Medicine, Osaka University
Developer Tetsuji Naka
Depositor Tetsuji Naka
Conditions of distribution In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1,2) designated by the depositor is requested. :contact us
Animal Health Report
Strain description

SOCS-5 Tg/line5-1 mice overexpress SOCS-5 under the control of β-actin promoter in whole body. It's said that SOCS-5 participate with control of helper T Cell differentiation through cytokine signal regulation. It also reported immuno response anomaly in this strain.
Reference(s)
  1. Ohshima M, Yokoyama A, Ohnishi H, Hamada H, Kohno N, Higaki J, and Naka T. (2007) Overexpression of suppressor of cytokine signalling-5 augments eosinophilic airway inflammation in mice. Clin. Exp. Allergy 37(5):735-42. [PMID:17456221]
  2. Seki Y, Hayashi K, Matsumoto A, Seki N, Tsukada J, Ransom J, Naka T, Kishimoto T, Yoshimura A, and Kubo M. (2002) Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc. Natl. Acad. Sci. U.S.A. 99(20):13003-8. [PMID:12242343]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Socs5
Gene name Suppressor of cytokine signaling 5
Genotyping information