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Strain Detail: SOCS1 KO (C57BL/6J congenic) mice
|Strain name||SOCS1 KO (C57BL/6J congenic)|
|Institution||Faculty of Medicine, Osaka University|
|Conditions of distribution||In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 4) designated by the depositor is requested. contact us|
|Animal Health Report|
SOCS1 (Suppressor of cytokine signaling 1) is a one of the signal transduction inhibitor, also called JAB (JAK-binding protein) or SSI (STAT-induced STAT inhibitor) -1. In 1997, it was found that SOCS1 was a molecule suppressing cytokine signal transduction to inhibit actiovation of JAK, a important cytokine signal transduction factor, by binding to JAK after being induced to express by cytokine (1-3). SOCS1 has one SH2 domain in the central region and conserved C-terminal domain (SC-motif/SOCS-box/CH-domain). This structural characteristic suggests that the SOCS family consists of at least 8 members.
Nakaet al. (Faculty of Medicine, Osaka University) produced congenic mice derived from two types of gene background, BALB/c and C57BL/6J after producing knockout mice using ES cells derived from 129 strain mice (4). We're available for supply of these two lines. SOCS1 KO mice are lethal before weaning caused by anomaly of immune cells. These mice decrease lymphoid cell by facilitation of apoptosis though differentiation of lymphocytes in thymus or spleen is normal. This strain is available for the research of cytokine signal transduction or immune system.
|From other institutions||Genotype|
|Cryopreserved embryo||In-house||Mating System|
|From other institutions||Mating System|
|Strain status / Availability||Cryopreserved sperm||Within 1 month|
|Cryopreserved embryo||Within 1 month|
|Live animals||Approx. 2 months|
|Gene name||Suppressor of cytokine signaling 1|