HOME > mice > SOCS1 KO mice (C57BL/6J congenic)

Strain Detail

Strain information
Resource No. nbio058
Strain name SOCS1 KO (C57BL/6J congenic)
Strain Nomenclature
Common name/Synonyms
Strain types congenic
Background strain
Institution Faculty of Medicine, Osaka University
Developer Tetsuji Naka
Depositor Tetsuji Naka
Conditions of distribution In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 4) designated by the depositor is requested. : contact us
Animal Health Report
Strain description

SOCS1 (Suppressor of cytokine signaling 1) is a one of the signal transduction inhibitor, also called JAB (JAK-binding protein) or SSI (STAT-induced STAT inhibitor) -1. In 1997, it was found that SOCS1 was a molecule suppressing cytokine signal transduction to inhibit actiovation of JAK, a important cytokine signal transduction factor, by binding to JAK after being induced to express by cytokine (1-3). SOCS1 has one SH2 domain in the central region and conserved C-terminal domain (SC-motif/SOCS-box/CH-domain). This structural characteristic suggests that the SOCS family consists of at least 8 members.

Naka et al. (Faculty of Medicine, Osaka University) produced congenic mice derived from two types of gene background, BALB/c and C57BL/6J after producing knockout mice using ES cells derived from 129 strain mice (4). We're available for supply of these two lines. SOCS1 KO mice are lethal before weaning caused by anomaly of immune cells. These mice decrease lymphoid cell by facilitation of apoptosis though differentiation of lymphocytes in thymus or spleen is normal. This strain is available for the research of cytokine signal transduction or immune system.

References
  1. Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ. A family of cytokine-inducible inhibitors of signalling. Nature (London). 1997;387:917-921.
  2. Endo T A, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A. A new protein containing an SH2 domain that inhibits JAK kinases. Nature (London). 1997;387:921-924.
  3. Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T. Structure and function of a new STAT-induced STAT inhibitor. Nature (London).1997;387:924-929.
  4. Naka T, Matsumoto T, Narazaki M, Fujimoto M, Morita Y, Ohsawa Y, Saito H, Nagasawa T, Uchiyama Y, Kishimoto T. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15577-82.
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Socs1
Gene name Suppressor of cytokine signaling 1
Genotyping information