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Strain Detail: Tak1flox mice
|Institution||Research Institute for Microbial Diseases, Osaka University|
|Conditions of distribution||It's necessary to obtain depositor's consent on use of biological resources. contact us|
|Animal Health Report|
TGF-β-activated kinase 1 (TAK1) is belong to mammalian MAP kinase kinase kinase (MAPKKK) family encoding in Map3k7 gene.
TAK1flox mice is established by crossing between C57BL/6 strain and chimera by using ES cells derived from 129/Ola strain (E14.1) introduced two loxP sites flanking exon 2 of Map3k7 by gene targeting. It's possible to delete TAK1 gene by crossing with Cre expressing mice. Especially, it's possible of stage- or organ-specific delation by selecting promoter induced expression of Cre recombinase, thus TAK1flox mice are useful for the research of stage- or tissue-specific TAK1.
Though TAK1 knockout mice were also produced by crossing with mice expressing Cre in germ cells, these mice were embryonic lethal (1). Furthermore, Tak1flox mice are observed abnormality of Toll-like receptor/IL-1R signal by tissue-specific knockout.
|From other institutions||Genotype|
|Cryopreserved embryo||In-house||Mating System|
|From other institutions||Mating System|
|Strain status / Availability||Cryopreserved sperm||Within 1 month|
|Cryopreserved embryo||Within 1 month|
|Live animals||Approx. 2 months|
|Mutation types||conditional KO|
|Gene symbol||Tak1, Map3k7|
|Gene name||TGF-β-activated kinase 1, Mitogen-activated protein kinase kinase kinase 7|