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Strain Detail: Tnfrsf1b KO mice

Strain information
Resource No. nbio350
Strain name Tnfrsf1b KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N
Institution Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition
Developer Osamu Suzuki
Depositor Osamu Suzuki
Conditions of distribution Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

A mouse strain in which the Tnfrsf1b gene was knocked out by genome editing (CRISPR / Cas9). It was created by setting gRNAs at two exons 2 and 3 of the Tnfrsf1b gene and deleting the middle part of the coding region. The Tnfrsf1b gene is involved in pulmonary fibrosis as well as TNF-induced inflammatory and immune responses.This strain is useful for studying these diseases.

Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Tnfrsf1b
Gene name tumor necrosis factor receptor superfamily, member 1b
Genotyping information